DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P44093_2000364 MC32196 A0A543KQI1_32196 1-381 1-386 0.92 1.0 0.88 0.93 0.93 0.82 39.4
P09545_2001445 MC32160 A0A353EWE1_32160 1-73 29-98 0.86 0.68 0.35 0.3 0.3 0.5 16.0
Q8U034_2000385 MC32133 L1K015_32133 19-176 6-62 0.9 0.92 0.3 0.78 0.78 0.75 12.6
Q6UV28_2001035 MC32131 A0A428YSV4_32131 6-121 2-117 0.96 0.98 0.94 0.97 0.97 0.95 54.3
Q8I917_2001623 MC32119 A0A6J0RI70_32119 1-56 6-61 1.0 0.41 0.97 0.4 0.4 0.93 26.7
Q9BMP1_2000558 MC32112 A0A068SE18_32112 1-149 3-151 0.99 0.83 0.98 0.82 0.82 0.99 63.0
P0ACB0_2000454 MC32007 A0A447RA91_32007 1-101 6-106 0.99 0.58 0.98 0.58 0.58 0.98 69.3
P12770_2000850 MC3199 A0A3N5YJH9_3199 1-92 1-92 0.99 1.0 0.97 0.98 0.98 0.98 72.8
Q8WYH8_2000898 MC3197 A0A177WT71_3197 1-52 29-80 1.0 0.65 1.0 0.65 0.65 1.0 73.0
A7B6R4_2001395 MC31923 D6DJ83_31923 2-100 33-131 0.98 0.71 0.91 0.67 0.67 0.85 31.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.