DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P70581_2001321 MC9898 K9J1P0_9898 1-86 96-181 1.0 0.32 0.99 0.31 0.31 1.0 96.5
Q7RTV0_2001266 MC9852 A0A2H9TJD7_9852 9-89 1-81 0.9 1.0 0.9 1.0 1.0 0.95 66.6
P0A6R0_2000091 MC9836 A0A2X3BZU6_9836 1-174 1-174 1.0 0.79 1.0 0.79 0.79 0.99 86.7
P35813_2000566 MC9799 A0A498N651_9799 1-71 8-79 0.99 0.67 0.96 0.65 0.65 0.95 70.8
P74396_2001490 MC9793 A0A4Q2WQJ8_9793 12-118 1-108 0.87 1.0 0.78 0.87 0.87 0.79 33.0
P11686_2001418 MC9764 A0A3Q2TYA3_9764 5-108 78-160 0.94 0.51 0.55 0.39 0.39 0.61 23.5
Q9WY59_2000038 MC9733 A0A388QA21_9733 1-280 4-283 1.0 0.57 0.99 0.57 0.57 0.95 56.4
P15468_2001173 MC9724 P15468_9724 1-117 15-131 0.98 0.89 0.98 0.89 0.89 0.98 100.0
Q9WYV0_2000953 MC9630 A0A5C6DIN9_9630 1-53 85-137 1.0 0.33 0.98 0.33 0.33 0.98 56.6
P46889_2000125 MC9592 A0A7Z7KPK6_9592 1-84 7-90 1.0 0.89 1.0 0.89 0.89 1.0 83.3
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.