DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9UXR8_2000018 MC1025 A0A0V0QZY2_1025 12-101 73-170 0.88 0.17 0.6 0.13 0.13 0.79 9.0
Q9KPS1_2000778 MC1023 A0A090RGW4_1023 1-157 3-159 0.99 0.68 0.99 0.67 0.67 0.98 73.8
P19400_2000863 MC10225 A0A183TZ62_10225 10-127 25-164 0.8 0.85 0.4 0.36 0.36 0.51 18.3
Q9X2D0_2001316 MC10213 A0A7V1ZGD0_10213 4-122 2-131 0.97 0.97 0.82 0.75 0.75 0.74 19.4
Q92PG6_2000832 MC10211 A0A2P6NFW3_10211 1-401 24-431 1.0 0.95 0.99 0.92 0.92 0.97 65.4
P05067_2000724 MC10173 A0A2Y9QSU6_10173 1-64 10-73 1.0 0.63 0.99 0.63 0.63 1.0 100.0
A0A0D9RBI8_2001067 MC10171 A0A452TJB2_10171 1-89 66-154 0.99 0.48 0.98 0.47 0.47 0.99 91.0
P77243_2000177 MC10068 A0A0B7IYJ2_10068 3-233 1-231 0.84 1.0 0.84 1.0 1.0 0.91 82.2
Q6Y3X3_2000591 MC10004 A0A455VIL0_10004 1-186 2-187 1.0 0.92 1.0 0.92 0.92 1.0 78.4
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.