DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
B3EYN9_2000223 MC31916 A0A2D5G2J6_31916 1-113 98-208 0.97 0.53 0.91 0.51 0.51 0.84 30.9
Q9S7T8_2000957 MC31889 A0A445CBV1_31889 71-388 2-316 0.81 0.99 0.78 0.96 0.96 0.81 61.2
Q8TNK0_2000346 MC31828 A0A7V5CHM9_31828 3-98 4-99 0.98 0.97 0.9 0.89 0.89 0.91 32.2
Q96C86_2000828 MC31739 A0A7J7S1J1_31739 10-98 1-87 0.82 1.0 0.8 0.99 0.99 0.87 93.2
A0A140N7N4_2001254 MC31677 A0A2D3T6Q3_31677 1-112 2-113 1.0 0.95 0.99 0.94 0.94 0.99 74.1
Q9K0T5_2000317 MC31625 A0A6N9HP15_31625 26-160 2-135 0.82 0.98 0.79 0.95 0.95 0.74 33.0
Q9KPA2_2000859 MC31568 A0A7K4E439_31568 3-78 1-76 0.88 0.99 0.86 0.96 0.96 0.87 35.5
P30613_2000325 MC31420 A0A287AQJ5_31420 2-134 45-177 0.99 0.75 0.99 0.75 0.75 0.97 57.1
P61431_2000593 MC31335 A0A6L4YQE9_31335 1-109 76-186 1.0 0.59 0.96 0.56 0.56 0.93 29.7
P06149_2000573 MC31335 A0A7V8FD07_31335 2-265 34-298 1.0 0.46 0.99 0.45 0.45 0.95 59.6
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.