DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9NQW7_2000099 MC32740 A0A210PP74_32740 1-247 58-305 1.0 0.76 0.99 0.76 0.76 0.97 68.1
P50579_2000147 MC32740 A0A3N0YVB0_32740 1-74 193-266 1.0 0.28 1.0 0.28 0.28 1.0 93.2
Q8L8B8_2000430 MC32561 A0A0E0KLT1_32561 2-181 4-183 0.98 0.98 0.98 0.98 0.98 0.98 76.6
P07357_2000234 MC32536 P07357_32536 1-315 13-327 1.0 0.88 1.0 0.88 0.88 1.0 100.0
Q82PP4_2001074 MC32416 A0A1V5MV34_32416 1-156 150-301 0.98 0.5 0.86 0.47 0.47 0.81 34.5
Q3YBR2_2001630 MC32302 H3AZ42_32302 1-145 50-194 0.99 0.59 0.99 0.59 0.59 0.99 75.1
Q8IJ45_2001172 MC3229 A0A2P9CH85_3229 1-284 82-365 0.96 0.77 0.78 0.64 0.64 0.68 37.4
Q96JA3_2001220 MC32286 G1LJ64_32286 1-200 10-209 0.95 0.95 0.95 0.95 0.95 0.96 98.5
P00157_2000616 MC3221 D3JC06_3221 1-107 186-292 0.9 0.37 0.9 0.37 0.37 0.94 83.1
Q9Y4K3_2000684 MC322 A0A5E4B0U9_322 1-25 84-108 1.0 0.16 0.99 0.16 0.16 1.0 92.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.