DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P00349_2000154 MC3705 A0A507FAL0_3705 2-210 13-221 1.0 0.69 0.99 0.69 0.69 0.99 72.2
P06710_2000447 MC36930 A0A6A5KTQ1_36930 1-126 52-177 1.0 0.32 1.0 0.32 0.32 0.99 84.9
Q5JIH3_2001401 MC36909 A0A842L3M0_36909 25-134 2-111 0.81 0.99 0.8 0.97 0.97 0.85 69.0
P08245_2000884 MC36759 A0A1G4XR26_36759 1-81 19-99 1.0 0.82 0.95 0.78 0.78 0.94 92.5
A6KY75_2001379 MC36605 A0A391P1L6_36605 2-65 99-162 0.98 0.4 0.96 0.39 0.39 0.95 32.8
P46947_2001434 MC36598 G0QIR8_36598 1-34 162-195 0.97 0.16 0.95 0.16 0.16 0.98 47.0
O26735_2000461 MC36575 A0A7T5RTG4_36575 15-136 1-123 0.87 0.99 0.84 0.95 0.95 0.8 35.7
Q5SJB8_2000617 MC36574 A0A0F9X986_36574 11-223 3-221 0.82 0.99 0.79 0.93 0.93 0.87 43.3
Q9FI56_2000839 MC36496 R0FMD1_36496 2-145 10-153 0.99 0.86 0.99 0.86 0.86 0.99 99.3
Q9HAU4_2000592 MC36357 A0A4Y9YEZ5_36357 2-331 10-339 0.88 0.97 0.86 0.94 0.94 0.86 51.2
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.