DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q1R9C1_2000179 MC375 A0A1M6JZX1_375 6-167 2-166 0.96 0.96 0.86 0.85 0.85 0.84 33.7
U6S0Y1_2001176 MC37459 A0A450TA33_37459 8-170 1-163 0.82 1.0 0.81 1.0 1.0 0.86 63.1
P0A8V6_2000043 MC37426 N1NRU3_37426 1-133 85-217 0.96 0.61 0.95 0.61 0.61 0.96 64.6
Q9PM40_2001123 MC37319 A0A1V5UX05_37319 5-146 2-147 0.97 0.75 0.94 0.72 0.72 0.91 42.4
P06134_2000880 MC3731 A0A539CVY6_3731 10-91 4-85 0.89 0.23 0.85 0.23 0.23 0.91 51.2
Q9Y6F1_2000489 MC37300 A0A7R8W7D3_37300 20-113 2-96 0.8 0.99 0.79 0.96 0.96 0.89 50.5
O31858_2000168 MC373 A0A7W5MBZ0_373 2-110 3-100 0.94 0.97 0.54 0.6 0.6 0.51 11.1
Q9Y052_2000371 MC37290 A0A2A6B4T4_37290 1-290 6-295 1.0 0.97 1.0 0.97 0.97 0.98 69.6
Q6IBS0_2000318 MC37263 A0A2K5CK34_37263 1-132 1-132 1.0 0.96 1.0 0.96 0.96 1.0 99.2
Q9FT92_2001042 MC37099 A0A453LEG9_37099 1-64 7-70 0.98 0.7 0.91 0.66 0.66 0.91 32.8
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.