DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P0A6Y5_2001189 MC36300 A0A090R139_36300 1-61 85-145 0.98 0.42 0.92 0.4 0.4 0.95 50.8
P22681_2000185 MC36271 A0A6I9MUC5_36271 1-88 1-88 1.0 0.82 1.0 0.82 0.82 1.0 95.4
A0A0H2V7J1_2001327 MC36261 A0A3B8W8Y7_36261 1-93 1-93 1.0 0.87 0.99 0.86 0.86 0.97 60.2
Q9UM54_2001470 MC36227 A0A7J8KD46_36227 8-116 1-109 0.87 1.0 0.86 0.99 0.99 0.92 97.2
Q9SA56_2000603 MC36165 Q9SA56_36165 27-142 1-116 0.81 1.0 0.81 1.0 1.0 0.87 100.0
Q8Y8H5_2000340 MC36130 W7DZI4_36130 1-131 5-135 0.9 0.97 0.9 0.96 0.96 0.93 74.8
Q82US3_2000341 MC36121 A0A2D8J5A5_36121 33-326 2-293 0.9 1.0 0.79 0.88 0.88 0.69 31.2
Q5IRN4_2001179 MC36071 A0A6P7ZAP7_36071 1-92 3-94 1.0 0.98 1.0 0.98 0.98 1.0 83.6
Q5A6R1_2000195 MC36037 A0A1V6SWC9_36037 1-190 1-190 0.94 1.0 0.94 1.0 1.0 0.99 84.7
Q9X1H2_2000003 MC36025 A0A7C2KEC5_36025 1-186 1-186 0.92 1.0 0.92 1.0 1.0 0.95 97.8
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.