DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q8YNP7_2000801 MC8376 A0A1I8Q6V4_8376 1-47 8-54 0.9 0.27 0.8 0.25 0.25 0.89 8.5
A0A4V8GZQ9_2000619 MC8359 P22534_8359 2-619 29-646 1.0 0.96 1.0 0.96 0.96 1.0 99.0
Q47PI5_2001358 MC8352 A0A1G9BE76_8352 6-184 2-182 0.97 0.95 0.9 0.87 0.87 0.82 46.9
P09884_2001077 MC8307 A0A7J5XH56_8307 1-30 81-110 0.97 0.16 0.94 0.15 0.15 0.94 60.0
P28905_2000438 MC8280 A0A5M3WS55_8280 21-146 116-267 0.86 0.27 0.51 0.16 0.16 0.44 13.4
Q12285_2001438 MC8269 A0A3C1QQP1_8269 1-41 67-103 0.85 0.25 0.41 0.15 0.15 0.74 12.1
Q7P1H6_2001506 MC8262 A0A0D8D4G1_8262 9-75 2-69 0.85 0.99 0.8 0.92 0.92 0.81 44.1
Q8BW10_2000112 MC8231 A0A091CRN5_8231 1-66 253-318 1.0 0.16 1.0 0.16 0.16 1.0 84.8
Q8YR53_2001626 MC8213 A0A396HA59_8213 15-85 1-72 0.83 1.0 0.72 0.84 0.84 0.76 29.1
Q7MTT4_2000513 MC819 A0A7S3VNU7_819 9-111 48-172 0.93 0.59 0.63 0.37 0.37 0.67 12.8
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.