DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9KQG8_2001442 MC8168 A0A2G6EWT1_8168 1-112 280-391 1.0 0.22 0.99 0.22 0.22 0.99 70.5
P17998_2000785 MC8151 A0A6I1VZ82_8151 1-107 147-253 1.0 0.42 0.98 0.42 0.42 0.96 57.9
P00646_2000285 MC8151 A0A6M3HH83_8151 7-206 1-199 0.86 1.0 0.85 0.99 0.99 0.87 68.0
Q9UI95_2000132 MC8131 A0A6A4SNK7_8131 2-139 5-142 0.99 0.82 0.99 0.82 0.82 0.98 89.1
J9PBR6_2001287 MC8122 J9PBR6_8122 8-99 2-93 0.9 0.99 0.9 0.99 0.99 0.95 100.0
Q9X4Q6_2001510 MC8082 A0A3T1DS93_8082 2-193 3-194 0.95 0.98 0.95 0.98 0.98 0.97 73.4
P83852_2000522 MC808 A0A6J0HRP2_808 1-79 309-387 1.0 0.11 1.0 0.11 0.11 1.0 91.1
P01180_2000646 MC8070 A0A835ZUL6_8070 1-79 1-79 1.0 0.82 1.0 0.82 0.82 1.0 98.7
P9WP21_2001102 MC8065 A0A6J6R032_8065 1-154 9-162 1.0 0.94 1.0 0.94 0.94 1.0 79.8
P40699_2001148 MC8036 A0A3D1C8L6_8036 3-65 110-172 0.97 0.35 0.9 0.34 0.34 0.92 47.6
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.