DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O26871_2000692 MC8570 A0A2E1RGW4_8570 1-150 2-108 0.99 0.97 0.42 0.55 0.55 0.37 10.6
Q53WA3_2001591 MC8570 A0A7W0WSD7_8570 22-113 116-220 0.8 0.47 0.36 0.2 0.2 0.51 18.5
Q9WYN9_2000203 MC8570 V8C568_8570 3-189 9-130 0.99 0.94 0.39 0.52 0.52 0.38 6.9
Q949P3_2001180 MC8564 A0A314XU33_8564 42-359 2-318 0.88 1.0 0.87 0.98 0.98 0.9 86.4
O43617_2001021 MC8534 A0A315UW90_8534 1-159 5-163 1.0 0.92 1.0 0.92 0.92 0.99 88.0
Q9NQC7_2000820 MC8518 A0A485N9D0_8518 1-57 335-391 1.0 0.11 1.0 0.11 0.11 1.0 98.2
U5KQB1_2000002 MC8415 A0A1K0FU75_8415 1-134 29-162 1.0 0.82 1.0 0.82 0.82 1.0 87.3
Q9S0B8_2001415 MC8402 A0A1D6H3S4_8402 3-133 31-178 0.97 0.58 0.5 0.31 0.31 0.44 11.3
Q95RR6_2000353 MC8385 A0A4C1YQZ6_8385 1-144 7-150 1.0 0.89 1.0 0.89 0.89 1.0 86.8
Q8GT36_2000379 MC8377 A0A1B0DK79_8377 1-68 35-88 0.82 0.37 0.2 0.13 0.13 0.62 14.7
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.