DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O59245_2000167 MC45389 A0A808TI74_45389 83-466 26-403 0.82 0.94 0.79 0.91 0.91 0.86 50.5
Q9I0H2_2000235 MC45369 Q08RM3_45369 2-117 20-135 0.99 0.86 0.98 0.85 0.85 0.98 67.2
Q9BSL1_2000157 MC45362 S9YRQ2_45362 1-44 103-146 1.0 0.14 0.99 0.14 0.14 1.0 93.1
Q5AP80_2001432 MC45323 A0A409Y823_45323 30-254 2-134 0.85 0.94 0.33 0.59 0.59 0.44 13.3
P60473_2000399 MC45244 A0A4U9HJ76_45244 7-221 1-215 0.94 1.0 0.94 0.99 0.99 0.97 93.0
P51123_2000782 MC4524 A0A535VT31_4524 9-67 17-77 0.88 0.43 0.35 0.21 0.21 0.51 15.1
P80372_2000667 MC45182 A0A6A5LCB2_45182 1-101 93-193 1.0 0.52 0.99 0.52 0.52 0.97 55.4
O54308_2001536 MC4512 V6Z4B8_4512 11-104 159-242 0.81 0.34 0.58 0.29 0.29 0.55 20.2
K7ZUA3_2000708 MC45027 K7ZUA3_45027 68-571 1-504 0.85 1.0 0.85 1.0 1.0 0.96 100.0
P56703_2000526 MC4501 A0A498N6A7_4501 1-62 141-202 1.0 0.31 0.99 0.31 0.31 1.0 93.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.