DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q03689_2001333 MC45800 A0A439DHD2_45800 8-65 175-230 0.89 0.24 0.59 0.19 0.19 0.55 24.5
Q03689_2001332 MC45800 A0A2I2GFA2_45800 2-208 4-215 0.99 0.88 0.92 0.8 0.8 0.82 28.6
P77836_2001000 MC45699 A0A077ZDA5_45699 2-258 73-329 0.99 0.78 0.98 0.77 0.77 0.96 73.1
P77836_2000268 MC45699 A0A7E4RZW9_45699 1-70 1-70 1.0 0.21 1.0 0.21 0.21 1.0 70.0
Q01968_2000608 MC45679 A0A673ZSG1_45679 14-320 2-306 0.9 1.0 0.89 0.99 0.99 0.96 73.6
Q5T5Y3_2000418 MC45646 A1ZAU8_45646 2-118 40-156 0.99 0.68 0.98 0.68 0.68 0.94 48.7
D0VWX7_2001064 MC45639 D0VWX7_45639 4-94 1-91 0.97 1.0 0.97 1.0 1.0 0.98 100.0
P07801_2000333 MC45503 A0A171K0V4_45503 9-81 1-73 0.9 0.57 0.89 0.57 0.57 0.96 54.7
O53896_2001495 MC45404 A0A109S6U0_45404 1-87 11-97 0.99 0.9 0.99 0.89 0.89 0.99 98.8
A0A0H3MBY2_2001538 MC45391 A0A351CWT2_45391 5-149 1-239 0.97 0.98 0.71 0.46 0.46 0.59 8.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.