DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q05086_2001453 MC44992 A0A099NSD0_44992 3-60 82-141 0.91 0.4 0.81 0.36 0.36 0.79 22.9
Q87UX0_2000052 MC44978 A0A8B3GIG0_44978 1-130 48-177 1.0 0.68 1.0 0.68 0.68 1.0 100.0
Q9X2A1_2000675 MC44917 A0A452R2I5_44917 43-232 1-190 0.8 1.0 0.8 0.98 0.98 0.88 55.7
Q9UKU7_2001041 MC44844 A0A6A1Q9H0_44844 1-231 7-336 1.0 0.69 0.98 0.48 0.48 0.98 63.6
P04918_2001335 MC44732 L9LAH9_44732 2-103 7-108 0.99 0.94 0.99 0.94 0.94 1.0 80.3
Q9Y5J3_2000811 MC44729 A0A643CK06_44729 1-55 48-102 1.0 0.23 0.98 0.23 0.23 0.99 98.1
Q5YYT7_2000543 MC4469 A0A853EXD3_4469 1-110 20-129 1.0 0.81 0.99 0.81 0.81 0.99 67.2
Q3Y185_2000450 MC44616 H3NI29_44616 1-126 4-132 0.98 0.97 0.95 0.92 0.92 0.91 42.6
Q8A6E6_2001390 MC44606 A0A800CK58_44606 3-274 16-184 0.92 0.91 0.45 0.69 0.69 0.48 12.5
P52555_2000464 MC4452 W0RRT1_4452 6-96 277-367 0.86 0.21 0.44 0.14 0.14 0.55 15.2
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.