DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P54654_2000656 MC54233 A0A6P8HUW0_54233 1-162 1-162 0.92 0.99 0.89 0.95 0.95 0.85 36.4
Q9WY07_2001147 MC5423 Q5CBM7_5423 2-145 3-146 0.99 0.95 0.99 0.95 0.95 0.99 100.0
P56589_2001610 MC54220 A0A669ENI4_54220 1-322 17-327 0.98 0.95 0.91 0.91 0.91 0.91 72.6
P0C0S1_2000485 MC54092 A0A554LV71_54092 2-84 20-122 0.94 0.69 0.75 0.46 0.46 0.83 15.5
P39748_2000658 MC54080 G1NRM5_54080 1-216 2-217 1.0 0.64 0.98 0.63 0.63 0.98 87.9
P18239_2000266 MC54033 A0A409V8H5_54033 7-282 2-277 0.93 0.99 0.91 0.98 0.98 0.93 76.0
Q6B9W9_2001460 MC53953 A0A7J0GL80_53953 1-103 29-132 1.0 0.56 0.86 0.49 0.49 0.91 42.3
Q79EF9_2001032 MC53916 A0A438B417_53916 1-273 50-321 0.98 0.84 0.96 0.84 0.84 0.94 59.7
O24883_2001306 MC53786 T2T319_53786 1-208 7-215 0.99 0.97 0.87 0.86 0.86 0.87 76.0
A0A3S5Y0S3_2001365 MC5378 A0A067PBH1_5378 1-113 47-152 1.0 0.7 0.83 0.63 0.63 0.75 23.4
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.