DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9HII6_2001085 MC53757 A0A0A1MCS3_53757 7-135 4-82 0.96 0.92 0.36 0.52 0.52 0.42 9.7
Q9Y5N6_2000494 MC53651 A0A2Y9KZ79_53651 1-92 93-184 0.99 0.46 0.99 0.46 0.46 0.99 95.6
P06612_2001097 MC53648 Q1D812_53648 1-328 3-365 1.0 0.78 0.95 0.68 0.68 0.9 46.8
A0A0E0TG05_2001256 MC5360 D0VX13_5360 1-116 3-118 0.99 0.98 0.99 0.98 0.98 0.99 99.1
O07517_2000864 MC5358 A0A1B2N6I7_5358 1-110 40-147 0.98 0.33 0.49 0.2 0.2 0.57 16.1
P69968_2000819 MC5358 A0A838AYE0_5358 5-85 244-326 0.89 0.25 0.82 0.24 0.24 0.8 22.8
O95831_2000021 MC53388 A0A835ZPB3_53388 2-345 3-346 1.0 0.94 1.0 0.94 0.94 1.0 96.8
P00390_2000020 MC53388 A0A1I7XS38_53388 1-114 281-394 0.99 0.28 0.93 0.27 0.27 0.84 40.5
P08165_2000155 MC53388 A0A6B0RI60_53388 1-395 24-418 1.0 0.91 1.0 0.91 0.91 1.0 99.4
A7ZET4_2001585 MC53322 A0A543DZJ1_53322 1-172 1-153 0.94 1.0 0.75 0.89 0.89 0.74 27.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.