DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q24368_2000065 MC54895 A0A6G1RW51_54895 1-102 41-141 1.0 0.31 0.75 0.25 0.25 0.91 74.5
Q1RCS1_2000429 MC54851 A0A377ZFE1_54851 1-98 4-101 1.0 0.48 0.98 0.48 0.48 0.97 69.3
P44941_2000028 MC54587 A0A7V2SL46_54587 1-15 34-48 1.0 0.15 0.87 0.14 0.14 0.99 73.3
Q8NBR6_2001570 MC54514 A0A674EPW5_54514 1-259 42-300 1.0 0.84 0.99 0.83 0.83 0.98 92.2
Q57594_2001071 MC54471 F0QQP8_54471 5-193 1-184 0.92 0.97 0.78 0.83 0.83 0.74 22.0
P39737_2000324 MC5446 D0ICA9_5446 11-108 8-91 0.91 0.92 0.49 0.58 0.58 0.62 19.0
Q8WWQ0_2001119 MC54442 Q8WWQ0_54442 1-116 23-138 1.0 0.71 1.0 0.71 0.71 1.0 100.0
Q8GY89_2000791 MC54344 A0A4S8JM00_54344 1-87 9-95 0.99 0.69 0.98 0.69 0.69 0.98 80.4
Q9WY43_2001060 MC54332 X0YTX8_54332 1-124 8-130 1.0 0.88 0.97 0.86 0.86 0.91 50.8
P0A8A0_2001120 MC54250 A0A0A2VCS0_54250 1-162 49-210 0.97 0.77 0.94 0.75 0.75 0.96 93.2
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.