DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q47184_2001223 MC6306 A0A5S9IRJ1_6306 12-149 132-232 0.86 0.26 0.55 0.24 0.24 0.67 8.6
P23023_2000541 MC63021 A0A6J2YR50_63021 1-52 4-55 1.0 0.52 0.97 0.51 0.51 1.0 76.9
P0AEU7_2000166 MC62917 A0A4R5HB08_62917 3-140 8-148 0.98 0.94 0.89 0.84 0.84 0.85 34.7
P12629_2000723 MC62797 A0A6S7PPD3_62797 1-125 9-133 1.0 0.91 1.0 0.91 0.91 1.0 85.6
V0A6S2_2001151 MC62698 A0A3G6Z234_62698 11-74 1-64 0.85 1.0 0.85 1.0 1.0 0.97 70.3
Q9Z0Y9_2000883 MC6265 S7N1D0_6265 1-235 98-332 0.98 0.71 0.98 0.71 0.71 0.98 97.4
O00268_2000943 MC62607 A0A822FB48_62607 3-97 12-106 0.98 0.76 0.97 0.76 0.76 0.98 95.7
Q9H081_2001416 MC6251 A0A6P5IEH2_6251 1-97 5-101 1.0 0.48 0.97 0.48 0.48 0.96 68.0
Q8IYV9_2000284 MC62481 A0A7N5P678_62481 1-113 21-133 1.0 0.63 0.98 0.62 0.62 0.95 59.2
P60057_2000479 MC62440 A0A287T4L4_62440 1-46 11-56 1.0 0.82 0.99 0.81 0.81 0.99 56.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.