DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q03555_2000456 MC63613 G3TYH9_63613 1-155 8-162 1.0 0.94 1.0 0.94 0.94 1.0 100.0
P84090_2000205 MC6353 A0A182SUK8_6353 2-100 3-101 0.99 0.98 0.97 0.96 0.96 0.96 57.5
Q9P868_2000917 MC6351 A0A1Y1VL05_6351 1-46 15-58 1.0 0.43 0.81 0.38 0.38 0.83 43.4
Q08698_2000586 MC63306 A0A376L9M5_63306 1-162 20-181 1.0 0.74 0.99 0.73 0.73 0.98 85.1
A9CLP4_2000548 MC63285 A0A5C4XA64_63285 31-237 1-205 0.85 1.0 0.82 0.97 0.97 0.87 74.3
Q8U3S9_2000431 MC6326 A0A662G194_6326 1-74 1-74 0.96 1.0 0.92 0.95 0.95 0.88 44.5
Q7A260_2000290 MC6316 A0A6B3M2M0_6316 2-134 27-159 0.99 0.84 0.93 0.79 0.79 0.87 48.1
P49458_2000623 MC6312 A0A674HCQ4_6312 1-71 2-72 0.96 0.97 0.95 0.96 0.96 0.96 84.5
Q9H7Z6_2000303 MC6310 A0A3S2UFT8_6310 1-215 119-333 1.0 0.64 1.0 0.64 0.64 0.99 95.8
A3D7B7_2001351 MC631 A0A246J352_631 5-182 5-177 0.91 0.97 0.78 0.86 0.86 0.69 16.7
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.