DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q57221_2000976 MC62384 A0A7C5FN03_62384 2-101 7-103 0.86 0.66 0.64 0.52 0.52 0.63 20.7
Q16829_2000246 MC62343 A0A556VWJ7_62343 1-146 9-154 1.0 0.9 1.0 0.9 0.9 1.0 94.5
P0ABS8_2001069 MC6232 A0A292AIR0_6232 3-66 2-65 0.84 0.94 0.84 0.93 0.93 0.94 59.3
P46531_2001047 MC6220 A0A183VB01_6220 2-34 70-103 0.94 0.33 0.84 0.31 0.31 0.86 41.1
Q3ACS3_2000314 MC6202 F8C3P6_6202 1-127 17-144 1.0 0.89 0.97 0.86 0.86 0.9 51.5
P37840_2001213 MC62009 Q5NL27_62009 2-116 25-146 0.82 0.36 0.56 0.25 0.25 0.86 16.2
Q9WYC4_2000951 MC62000 D7FSP8_62000 11-325 2-337 0.96 0.88 0.78 0.67 0.67 0.72 11.8
A8HQH2_2001015 MC6193 A8HQH2_6193 1-121 34-154 1.0 0.72 1.0 0.72 0.72 1.0 100.0
P16233_2000740 MC61922 A0A6B0RNC4_61922 2-113 1-112 0.99 0.93 0.99 0.93 0.93 0.99 74.1
Q9KWU8_2000068 MC6191 A0A6L5C598_6191 1-58 165-222 0.98 0.24 0.95 0.24 0.24 0.97 51.7
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.