DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9SSA5_2000165 MC64252 A0A199UG57_64252 3-191 1-189 0.94 1.0 0.93 0.99 0.99 0.94 86.7
Q931P4_2000051 MC64199 A0A0E1X4F7_64199 1-116 9-124 1.0 0.78 1.0 0.78 0.78 1.0 95.6
W5PPP6_2000016 MC64164 L5LTS9_64164 1-147 469-615 1.0 0.24 1.0 0.24 0.24 1.0 97.9
Q6PH85_2000120 MC6403 A0A7J5Y289_6403 1-76 91-166 1.0 0.38 1.0 0.38 0.38 1.0 90.7
O14684_2001033 MC64018 A0A7R5L108_64018 4-142 2-140 0.98 0.99 0.97 0.99 0.99 0.98 69.7
Q7SIF4_2000894 MC63950 A0A3B4E335_63950 12-557 1-339 0.8 1.0 0.39 0.76 0.76 0.44 13.5
P30958_2000946 MC6385 A0A7C4BPY6_6385 23-153 1-131 0.83 1.0 0.75 0.89 0.89 0.76 25.7
Q9Y3D8_2001257 MC63699 A0A836CU37_63699 1-147 1-147 1.0 0.83 1.0 0.83 0.83 1.0 89.7
Q8YUA0_2001547 MC63670 L1J175_63670 1-91 11-117 0.89 0.92 0.84 0.73 0.73 0.83 28.9
Q14493_2001289 MC63666 B3KSC5_63666 1-73 20-92 1.0 0.55 1.0 0.55 0.55 1.0 100.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.