DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9HU36_2001049 MC12231 A0A090S384_12231 1-74 1-74 0.94 0.97 0.9 0.94 0.94 0.91 55.4
Q54873_2000878 MC12212 A0A655MTR7_12212 2-76 200-274 0.99 0.26 0.99 0.26 0.26 0.99 100.0
P54494_2000753 MC1216 A0A2T4ZDN9_1216 1-60 7-66 0.98 0.86 0.97 0.85 0.85 0.97 38.3
Q9CIV8_2000263 MC12153 H5UTL8_12153 43-328 1-282 0.87 0.99 0.84 0.96 0.96 0.84 47.5
P13804_2000025 MC12014 G5AUJ5_12014 1-188 21-208 1.0 0.66 1.0 0.66 0.66 0.99 89.8
P76483_2000956 MC11963 A0A350EX78_11963 1-160 3-157 0.98 0.98 0.71 0.74 0.74 0.62 16.3
P52701_2001031 MC11922 A0A183AQ74_11922 1-65 19-83 1.0 0.59 0.99 0.58 0.58 1.0 69.2
Q9VAK8_2000014 MC11772 Q9VAK8_11772 1-91 21-111 1.0 0.82 1.0 0.82 0.82 1.0 100.0
P56682_2000599 MC11761 P56682_11761 1-56 1-56 1.0 1.0 1.0 1.0 1.0 1.0 100.0
Q9C005_2001144 MC11757 A0A7I8W3L5_11757 1-50 58-107 0.98 0.46 0.97 0.46 0.46 0.98 78.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.