DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P75966_2000390 MC11670 A0A8B4Z7V6_11670 2-178 3-179 0.97 0.99 0.97 0.99 0.99 0.98 86.4
Q9LV40_2001322 MC11662 A0A7G2DX05_11662 59-353 2-252 0.84 0.96 0.65 0.87 0.87 0.7 33.2
Q5KVB6_2001251 MC11648 A0A7V2LVB3_11648 1-140 2-141 1.0 0.96 0.99 0.95 0.95 0.98 70.7
P0A042_2000110 MC11647 A0A2W4KD26_11647 1-53 70-122 0.98 0.41 0.94 0.4 0.4 0.96 33.9
P54512_2000044 MC11647 A0A7X4FJJ3_11647 1-76 134-211 0.99 0.36 0.8 0.32 0.32 0.8 17.9
Q9PM41_2001156 MC11632 A0A5N5F508_11632 11-342 2-296 0.92 0.99 0.72 0.87 0.87 0.66 35.7
Q5MK11_2001228 MC11627 A0A4U0VSQ9_11627 1-101 1-100 0.98 1.0 0.93 0.96 0.96 0.88 45.0
Q6FF54_2000862 MC11516 A0A7J7BU55_11516 1-165 7-171 0.94 0.96 0.94 0.95 0.95 0.97 88.4
Q9BX68_2000204 MC11436 A0A2G8JFV9_11436 3-110 1-108 0.96 1.0 0.95 1.0 1.0 0.96 61.1
Q8CML1_2000580 MC11367 A0A1M6R6D9_11367 1-82 4-89 0.98 0.94 0.92 0.84 0.84 0.9 31.3
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.