DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q92888_2000532 MC12683 A0A7J7F042_12683 1-190 45-234 1.0 0.56 1.0 0.56 0.56 0.99 90.5
Q1LAJ1_2001576 MC12657 A0A127QEE7_12657 13-93 15-95 0.87 0.84 0.75 0.72 0.72 0.75 36.1
Q3M8Q7_2000574 MC12577 A0A7T5JF11_12577 3-130 1-129 0.98 1.0 0.9 0.91 0.91 0.83 41.5
P97571_2000760 MC12497 A0A836CV14_12497 2-159 31-191 0.99 0.44 0.97 0.43 0.43 0.94 87.5
P43026_2000537 MC12435 A0A4Z2BNQ6_12435 1-105 36-140 1.0 0.75 1.0 0.75 0.75 1.0 80.9
Q9Y221_2000326 MC12424 A0A813TGJ5_12424 1-91 1-91 0.97 1.0 0.96 0.99 0.99 0.97 64.8
A0A0A5IIP6_2001637 MC12416 A0A078ARC3_12416 1-77 102-194 1.0 0.48 0.53 0.23 0.23 0.57 7.0
Q9ZUB3_2000088 MC124 A0A2U1Q2K4_124 1-183 5-187 1.0 0.96 1.0 0.96 0.96 1.0 87.9
Q27783_2000773 MC124 A0A7X7ZJL9_124 23-216 1-152 0.89 1.0 0.4 0.51 0.51 0.37 13.3
G4SW86_2001428 MC1237 A0A1I8FMV3_1237 1-199 89-297 0.99 0.7 0.93 0.63 0.63 0.84 31.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.