DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
A0A384K8I9_2001076 MC13100 A0A6I5DRV8_13100 3-110 4-118 0.84 0.94 0.7 0.74 0.74 0.73 34.4
P58004_2001166 MC13008 A0A556TPD4_13008 1-144 249-392 1.0 0.37 1.0 0.37 0.37 0.99 79.1
Q6N0Y6_2000313 MC12974 A0A7Z2VTP5_12974 3-66 43-97 0.97 0.51 0.57 0.38 0.38 0.53 10.7
Q8C863_2000992 MC12932 A0A5E4B8P0_12932 1-31 37-67 1.0 0.32 0.99 0.32 0.32 1.0 87.0
O27953_2000283 MC12827 A0A818ZU59_12827 9-89 175-258 0.88 0.32 0.29 0.13 0.13 0.52 12.9
Q9UGP5_2000117 MC12784 A0A1D5PGM5_12784 1-57 146-202 1.0 0.15 1.0 0.15 0.15 1.0 85.9
Q6FVN3_2000499 MC12779 J7S2J4_12779 2-109 69-176 0.99 0.61 0.91 0.56 0.56 0.89 58.0
P33678_2000674 MC12747 P00266_12747 1-62 1-63 1.0 1.0 0.97 0.96 0.96 0.96 71.4
P0A734_2000977 MC1271 A0A3M1FPG4_1271 1-57 24-79 0.98 0.66 0.68 0.49 0.49 0.7 21.0
P49917_2001571 MC12686 A0A6A1Q7S2_12686 2-28 75-101 0.96 0.23 0.95 0.23 0.23 0.97 92.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.