DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P00172_2000053 MC13488 A0A6B0RZW8_13488 1-87 6-92 1.0 0.9 1.0 0.89 0.89 1.0 97.7
Q01855_2000449 MC13428 A0A803LFG8_13428 1-80 28-107 1.0 0.64 0.99 0.63 0.63 0.99 70.0
Q46944_2000402 MC13419 A0A7W4G2G6_13419 2-110 26-124 0.99 0.64 0.85 0.61 0.61 0.83 43.1
Q9S7M0_2000269 MC13415 A0A453A0P7_13415 1-205 6-210 1.0 0.94 1.0 0.94 0.94 1.0 94.6
Q51739_2000704 MC13311 A0A7C5EDM2_13311 74-390 3-300 0.8 0.99 0.63 0.81 0.81 0.53 23.2
Q9BRT9_2000971 MC13298 A0A1V4KHJ9_13298 1-145 19-163 1.0 0.66 0.99 0.65 0.65 0.99 82.0
O34401_2000186 MC13266 A0A164VM30_13266 2-132 1-131 0.98 0.99 0.98 0.99 0.99 0.98 100.0
F9UQB2_2000793 MC13218 A0A0F4KRD8_13218 18-109 1-92 0.81 0.99 0.75 0.9 0.9 0.75 34.7
Q87I71_2000967 MC13170 A0A5K7Z1P7_13170 5-177 208-381 0.98 0.43 0.94 0.42 0.42 0.85 37.9
O86283_2000559 MC13106 A0A2P9IK48_13106 2-65 51-120 0.97 0.53 0.76 0.41 0.41 0.68 12.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.