DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
L7MTK3_2001124 MC13803 L7MTK3_13803 1-132 144-275 1.0 0.48 1.0 0.48 0.48 1.0 100.0
Q91642_2001534 MC138 H0E5Z9_138 39-231 1-192 0.8 0.93 0.61 0.7 0.7 0.52 16.0
G0SDS8_2001314 MC13789 R8BUE1_13789 1-101 7-107 1.0 0.9 1.0 0.9 0.9 1.0 93.0
W5P4E7_2000299 MC13759 A0A6I9MYP3_13759 2-79 8-85 0.99 0.92 0.98 0.91 0.91 0.98 67.9
Q9YGN6_2000707 MC13724 A0A6P4Z6F9_13724 4-235 2-233 0.95 0.99 0.94 0.98 0.98 0.93 55.6
P28632_2000309 MC13724 A0A1Q3SEX7_13724 8-103 8-126 0.87 0.94 0.62 0.55 0.55 0.58 14.6
Q5SKU6_2001353 MC13673 A0A4Q0T2W5_13673 3-96 51-146 0.97 0.64 0.81 0.55 0.55 0.72 9.1
Q57XM6_2000411 MC1363 Q57XM6_1363 1-120 11-130 1.0 0.92 1.0 0.92 0.92 1.0 100.0
Q39580_2000524 MC13548 W7U288_13548 1-84 20-103 1.0 0.74 1.0 0.74 0.74 1.0 89.2
Q9UX16_2001150 MC13543 C3NH07_13543 7-189 1-183 0.97 0.94 0.96 0.93 0.93 0.97 91.8
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.