DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9CMQ1_2001268 MC14503 A0A0A2W3X4_14503 22-370 4-350 0.82 0.96 0.77 0.9 0.9 0.72 30.1
P05019_2000247 MC14434 A0A7E4S8S2_14434 2-61 23-82 0.97 0.71 0.68 0.52 0.52 0.7 38.3
Q9HYE3_2000818 MC14422 A0A657B6G0_14422 1-70 1-70 0.92 1.0 0.83 0.89 0.89 0.84 30.0
P14677_2000188 MC14355 A0A496LCT7_14355 1-56 74-129 0.97 0.43 0.96 0.43 0.43 0.97 62.5
Q8NRS3_2001593 MC14331 A0A839V3D3_14331 11-72 4-70 0.82 0.38 0.57 0.27 0.27 0.58 12.8
Q9HJL1_2001595 MC14190 A0A7G3DWR9_14190 1-108 1-103 0.98 0.54 0.49 0.32 0.32 0.53 14.4
P43268_2000146 MC14128 A0A6P3QPJ3_14128 1-81 49-129 1.0 0.56 1.0 0.56 0.56 1.0 96.2
Q9X519_2000546 MC14120 A0A0G1UD43_14120 1-234 50-311 1.0 0.69 0.95 0.59 0.59 0.89 41.8
Q46AP6_2000928 MC14115 A0A3M1RCV8_14115 2-125 15-138 0.99 0.9 0.98 0.88 0.88 0.96 63.7
Q9LX31_2001125 MC14114 A0A7S4KXK6_14114 9-155 32-191 0.95 0.83 0.86 0.7 0.7 0.84 38.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.