DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q14766_2000612 MC1411 A0A7F8RXU9_1411 3-63 1-59 0.84 1.0 0.66 0.8 0.8 0.7 35.4
P42778_2000251 MC14099 A0A8B5WQS8_14099 1-223 156-380 0.99 0.59 0.97 0.58 0.58 0.9 41.7
Q3MFD8_2000104 MC14080 A0A316V989_14080 1-30 8-37 0.97 0.12 0.88 0.12 0.12 0.94 13.3
Q05H60_2001286 MC14071 Q2CID9_14071 14-124 11-110 0.89 0.21 0.56 0.18 0.18 0.54 15.3
Q1D0A0_2001323 MC14071 A0A812YN14_14071 1-109 207-315 0.99 0.34 0.97 0.34 0.34 0.92 33.9
Q9Y3E5_2000507 MC14056 A0A167FI50_14056 2-117 7-122 0.99 0.95 0.98 0.94 0.94 0.97 55.1
Q9X024_2000540 MC13999 E6LMG7_13999 14-194 5-187 0.87 0.98 0.79 0.87 0.87 0.75 33.3
P83755_2000475 MC13975 A0A484MYC1_13975 22-317 1-296 0.9 1.0 0.9 1.0 1.0 0.96 96.6
P20964_2000882 MC13965 A0A7Y4ZGZ5_13965 1-156 3-158 1.0 0.5 0.98 0.5 0.5 0.96 53.8
Q8RDB0_2000160 MC13872 X1QQU2_13872 1-34 3-36 1.0 0.37 0.99 0.37 0.37 0.99 58.8
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.