DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O26950_2001487 MC14882 A0A520KH27_14882 9-151 1-147 0.94 1.0 0.85 0.89 0.89 0.76 27.3
Q66DQ2_2000040 MC14882 A0A6A5KTQ1_14882 8-178 2-172 0.94 0.99 0.94 0.99 0.99 0.95 81.8
B5ZAD9_2001342 MC14860 A0A1V3BE91_14860 7-97 2-92 0.94 0.99 0.94 0.99 0.99 0.96 95.6
Q5SHS3_2000145 MC14823 A0A1B9F315_14823 1-59 8-66 0.98 0.6 0.96 0.59 0.59 0.93 50.8
P39571_2001617 MC14696 A0A356U768_14696 1-277 23-305 0.8 0.73 0.71 0.63 0.63 0.63 20.4
Q2T7I5_2000664 MC14630 A0A6A5L8G0_14630 76-424 2-350 0.81 0.99 0.81 0.98 0.98 0.92 70.2
Q99ZW2_2001501 MC14608 Q99ZW2_14608 1-269 106-374 1.0 0.72 1.0 0.72 0.72 1.0 100.0
P23367_2000981 MC14553 A0A3B0IXC8_14553 2-179 79-256 0.98 0.69 0.94 0.67 0.67 0.88 39.3
P0AB64_2001429 MC1453 A0A6A1TMW4_1453 5-72 16-85 0.84 0.6 0.51 0.38 0.38 0.52 9.5
Q02936_2001210 MC14529 A0A182UCZ4_14529 1-145 7-149 1.0 0.87 0.98 0.87 0.87 0.96 51.7
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.