DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q93YB2_2000910 MC1531 A0A2P6VS16_1531 25-478 1-451 0.91 1.0 0.9 1.0 1.0 0.93 61.8
Q6N9A4_2001597 MC1527 A0A316LDJ7_1527 1-67 56-106 0.89 0.36 0.44 0.25 0.25 0.58 8.8
P02795_2000854 MC15228 A0A667HK04_15228 1-31 23-53 1.0 0.58 0.97 0.58 0.58 0.98 100.0
Q8TZE5_2001475 MC15099 A0A1F9FE61_15099 4-101 16-124 0.9 0.75 0.28 0.22 0.22 0.5 7.4
G1TJW1_2000320 MC15087 A0A7M4FHU7_15087 1-130 60-189 1.0 0.64 1.0 0.64 0.64 1.0 97.6
P07996_2000350 MC15017 A0A7M5U9K6_15017 1-121 433-552 1.0 0.15 0.97 0.15 0.15 0.95 48.7
O29321_2000997 MC15013 A0A7X5D4I4_15013 7-112 85-176 0.93 0.47 0.53 0.34 0.34 0.52 9.4
P0A7I7_2000322 MC14998 A0A1G1VHV1_14998 1-174 19-192 1.0 0.82 0.97 0.8 0.8 0.91 41.3
Q6W2J9_2000135 MC14992 Q6W2J9_14992 1-81 38-118 1.0 0.61 1.0 0.61 0.61 1.0 100.0
Q739E5_2001551 MC14918 M5WUA1_14918 8-144 133-275 0.93 0.48 0.34 0.19 0.19 0.51 12.1
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.