DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q6P179_2000297 MC15510 A0A5N4ECE4_15510 1-217 3-219 1.0 0.95 1.0 0.95 0.95 1.0 86.6
P0AFX7_2000881 MC15480 A0A376FKW3_15480 1-66 1-66 1.0 0.33 0.97 0.32 0.32 0.98 84.8
Q5L084_2000054 MC1545 A0A7V5RPN5_1545 2-211 337-546 1.0 0.38 0.99 0.38 0.38 0.98 69.5
Q5TDH0_2000671 MC15448 A0A7M4FGU9_15448 1-127 5-131 0.99 0.97 0.99 0.97 0.97 0.99 99.2
P21575_2001260 MC15433 A0A667YSA6_15433 1-261 17-277 1.0 0.93 1.0 0.92 0.92 1.0 91.5
Q8BH64_2001559 MC15433 A0A4D6MV22_15433 1-107 244-350 0.92 0.3 0.88 0.3 0.3 0.91 44.8
P40486_2001611 MC15402 A0A0X8HSK3_15402 2-340 1-328 0.99 0.99 0.94 0.98 0.98 0.95 62.2
P45923_2001211 MC1540 R6MYT4_1540 4-115 2-86 0.86 0.98 0.51 0.74 0.74 0.6 16.3
Q9S9F3_2000528 MC15367 A0A3Q7I8R1_15367 1-67 161-227 1.0 0.3 0.98 0.29 0.29 0.96 38.8
F1S3W0_2000518 MC15366 A0A1S3W8Y6_15366 1-64 20-83 1.0 0.77 1.0 0.77 0.77 1.0 93.7
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.