DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P29476_2000856 MC20246 Q9Z0J4_20246 22-416 2-396 0.94 1.0 0.94 1.0 1.0 0.97 98.4
Q3SJ38_2001578 MC20230 A0A1Y1QH32_20230 11-118 2-109 0.9 0.98 0.88 0.96 0.96 0.88 34.2
Q9P6Q6_2000874 MC20200 A0A1J8Q884_20200 12-259 1-258 0.95 1.0 0.9 0.91 0.91 0.86 37.9
P61011_2001186 MC20172 A0A819EY43_20172 1-106 32-137 0.99 0.61 0.94 0.59 0.59 0.95 78.3
Q92843_2001300 MC20050 A0A7I8WBP6_20050 9-169 10-172 0.95 0.93 0.79 0.77 0.77 0.7 18.2
Q97U11_2000742 MC19995 M1JAB0_19995 3-81 1-79 0.95 0.99 0.94 0.98 0.98 0.97 75.9
P76156_2000484 MC19934 E1JBX7_19934 2-127 7-132 0.99 0.93 0.98 0.92 0.92 0.97 80.9
Q64XJ4_2001514 MC1989 A0A351M481_1989 5-164 1-160 0.95 0.98 0.94 0.97 0.97 0.95 83.7
Q8VSC3_2001307 MC19852 A0A7T2JNM3_19852 2-276 191-465 0.98 0.59 0.96 0.58 0.58 0.94 75.2
Q9H361_2000187 MC19838 A0A5N4CU79_19838 1-76 12-87 1.0 0.85 0.99 0.85 0.85 1.0 75.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.