DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O53654_2001472 MC20540 A0A7I7NR05_20540 1-93 32-124 1.0 0.72 0.95 0.69 0.69 0.92 72.0
Q9ZVL6_2001523 MC20527 A0A0E0L2B1_20527 1-152 22-173 1.0 0.76 0.99 0.76 0.76 0.98 82.2
Q15366_2000648 MC20475 B4DLC0_20475 1-70 9-78 0.99 0.54 0.98 0.54 0.54 0.99 100.0
Q5LL55_2001588 MC2045 A0A2Z5YPH5_2045 3-68 1-56 0.93 0.45 0.56 0.34 0.34 0.62 15.1
Q5SGX1_2000444 MC20395 A0A401FKK8_20395 34-203 1-166 0.81 1.0 0.77 0.97 0.97 0.8 47.0
P31224_2000361 MC20313 A0A377YX07_20313 2-88 29-115 0.99 0.62 0.98 0.62 0.62 0.97 56.3
P10746_2000448 MC20310 A0A3P8TWK8_20310 3-223 2-223 0.85 0.97 0.81 0.92 0.92 0.87 54.5
P13702_2000904 MC20279 A0A845C5J1_20279 2-148 202-367 0.93 0.45 0.88 0.39 0.39 0.84 42.7
Q82U33_2000762 MC20254 A0A6S6S039_20254 1-79 1-72 0.93 0.91 0.52 0.55 0.55 0.57 20.2
P0AB44_2000312 MC20254 A0A2I8QWU0_20254 6-95 1-90 0.83 0.99 0.8 0.94 0.94 0.91 83.3
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.