DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q13439_2000660 MC19826 A0A0T6BBL8_19826 2-51 222-273 0.98 0.19 0.86 0.17 0.17 0.85 19.2
Q700S9_2000214 MC19808 A0A0A2LPK9_19808 1-97 1-96 1.0 0.62 0.87 0.56 0.56 0.79 35.3
P69786_2000219 MC19788 A0A7V9FGK6_19788 1-75 1-75 1.0 0.78 0.99 0.77 0.77 0.97 65.3
O57728_2001511 MC19783 A0A2A2K8K0_19783 5-77 1-75 0.95 0.75 0.93 0.72 0.72 0.93 36.0
P24203_2000788 MC19724 A0A7V2UGG1_19724 2-95 19-113 0.99 0.84 0.95 0.8 0.8 0.89 34.7
Q2V8X0_2000302 MC19689 P16969_19689 2-102 29-129 0.99 0.76 0.98 0.76 0.76 0.99 99.0
Q09472_2000941 MC19658 A0A1I7Z7D8_19658 1-102 4-105 0.93 0.93 0.89 0.89 0.89 0.93 49.0
P0AB98_2000351 MC1964 A0A800ANZ3_1964 9-171 36-175 0.95 0.8 0.63 0.62 0.62 0.63 29.4
Q9WZ49_2001231 MC19610 A0A5N6RAC8_19610 1-191 37-231 0.99 0.84 0.95 0.8 0.8 0.92 39.7
Q9KM02_2000781 MC1957 Q2JVA4_1957 1-130 9-138 1.0 0.94 0.96 0.91 0.91 0.91 46.1
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.