DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q8EAI7_2000938 MC21177 A0A1V5DMF3_21177 7-153 2-147 0.96 0.96 0.91 0.92 0.92 0.84 41.4
P99165_2001007 MC21126 A0A6V8M1G0_21126 2-278 4-278 0.86 0.99 0.84 0.98 0.98 0.87 58.8
Q8N5K1_2001288 MC21121 A0A4W5L680_21121 1-64 21-84 1.0 0.74 0.99 0.73 0.73 0.99 85.9
Q9Z4I2_2001450 MC20927 A0A1H8SMN1_20927 2-108 215-321 0.98 0.29 0.98 0.29 0.29 0.97 71.0
E2JF22_2001363 MC20890 E7FD74_20890 1-239 218-446 1.0 0.43 0.92 0.42 0.42 0.92 57.5
P0A8S9_2000210 MC2089 A0A084IMW8_2089 2-98 1-97 0.99 1.0 0.95 0.96 0.96 0.92 42.2
P51584_2001157 MC20776 A0A1V5MM98_20776 1-55 32-86 0.98 0.33 0.96 0.33 0.33 0.96 43.6
Q9RTX5_2001121 MC20763 A0A1R3K3Q1_20763 36-320 1-281 0.85 0.99 0.81 0.96 0.96 0.77 39.0
Q9XVR6_2001569 MC20644 A0A6H5I508_20644 36-220 3-184 0.8 0.95 0.74 0.89 0.89 0.77 36.5
Q9WXS2_2000058 MC20590 M2CG92_20590 2-298 10-306 0.9 0.97 0.89 0.96 0.96 0.88 53.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.