DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O28769_2000830 MC21523 A0A560TCG2_21523 2-54 158-210 0.98 0.25 0.93 0.25 0.25 0.93 28.3
Q13309_2000384 MC2149 A0A210PP07_2149 2-38 7-43 0.95 0.3 0.91 0.3 0.3 0.9 37.8
O27564_2000029 MC21482 A0A7C7Q1B2_21482 1-76 21-97 1.0 0.75 0.96 0.71 0.71 0.92 37.6
Q99385_2001338 MC2147 A0A364N1U7_2147 1-377 40-421 0.99 0.91 0.94 0.85 0.85 0.87 52.8
Q9JY98_2001072 MC21375 A0A6M8HTP7_21375 20-112 3-95 0.8 0.97 0.73 0.87 0.87 0.77 23.1
O48791_2001477 MC21364 A0A498K9W0_21364 1-46 21-66 0.98 0.35 0.97 0.35 0.35 0.98 89.1
O80337_2000174 MC21347 A0A0K9Q4N3_21347 1-63 18-80 1.0 0.52 0.99 0.52 0.52 0.98 73.0
P21853_2001138 MC21263 A0A7X7N1G6_21263 14-89 1-84 0.84 0.67 0.8 0.58 0.58 0.82 45.2
Q57764_2000659 MC21238 A0A497N863_21238 8-156 1-153 0.94 0.97 0.86 0.87 0.87 0.79 31.8
Q58588_2000810 MC212 A0A1F4U670_212 53-295 1-256 0.81 1.0 0.77 0.89 0.89 0.7 31.1
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.