DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O29535_2001199 MC21839 Q8TYG5_21839 38-275 1-268 0.84 0.78 0.7 0.58 0.58 0.65 34.3
Q9LQT8_2001632 MC21826 A0A811T371_21826 12-66 6-64 0.82 0.33 0.57 0.25 0.25 0.65 16.9
Q9RNX2_2001341 MC2180 A0A7C2NJE7_2180 63-497 1-435 0.86 1.0 0.81 0.94 0.94 0.82 40.7
Q8U3E5_2000199 MC21766 A0A7J3P553_21766 1-136 1-149 1.0 0.92 0.78 0.67 0.67 0.68 20.5
Q8YN91_2000017 MC21746 A0A3C1DTA1_21746 4-126 2-124 0.98 0.8 0.97 0.8 0.8 0.96 64.2
O67757_2000812 MC21683 O67757_21683 1-80 4-83 0.99 0.96 0.99 0.96 0.96 0.99 100.0
Q03759_2000401 MC21634 A0A319ETL7_21634 2-86 3-68 0.81 0.85 0.4 0.5 0.5 0.41 14.1
Q9X1S1_2000258 MC21599 A6TL35_21599 12-372 2-366 0.87 1.0 0.86 0.97 0.97 0.84 53.4
P61244_2001201 MC21554 A0A1A8RBE7_21554 1-52 13-64 1.0 0.49 1.0 0.49 0.49 1.0 100.0
P0AC98_2001565 MC2155 A0A023RJI0_2155 1-182 9-190 1.0 0.96 0.99 0.95 0.95 0.99 64.2
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.