DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P36929_2000437 MC22104 A0A7R8VTP6_22104 2-125 1-124 0.89 0.99 0.88 0.99 0.99 0.93 74.1
P22307_2000129 MC22031 L5K376_22031 1-115 1-115 0.94 1.0 0.94 1.0 1.0 0.96 97.3
Q96PS8_2000354 MC21954 A0A5C6NG40_21954 1-251 13-263 1.0 0.94 0.99 0.94 0.94 0.95 56.1
Q50EL0_2000920 MC21935 A0A178F5C7_21935 37-417 2-381 0.83 1.0 0.83 0.99 0.99 0.92 65.8
Q06988_2001281 MC21934 A0A3E0L684_21934 3-85 221-317 0.98 0.3 0.53 0.18 0.18 0.52 9.0
P82650_2001270 MC21913 F1NXX2_21913 1-242 6-247 1.0 0.83 1.0 0.83 0.83 0.99 69.8
P55847_2000722 MC21912 D0EZP2_21912 2-78 20-95 0.99 0.8 0.9 0.74 0.74 0.87 41.5
P49344_2001145 MC21909 H9JK70_21909 6-33 137-164 0.82 0.13 0.75 0.13 0.13 0.78 14.2
O34306_2001602 MC2190 A0A0A3Z3W0_2190 1-84 1-93 0.99 0.82 0.56 0.45 0.45 0.56 11.2
O31533_2000131 MC21857 A0A645H737_21857 2-61 19-78 0.98 0.77 0.93 0.74 0.74 0.9 30.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.