DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P13476_2000889 MC24749 L3CGZ6_24749 1-82 30-111 0.99 0.74 0.97 0.73 0.73 0.97 100.0
Q9UHB9_2000085 MC24698 A0A480NR28_24698 1-197 13-209 1.0 0.92 1.0 0.92 0.92 1.0 99.4
Q97Q59_2001029 MC24660 A0A242K8M6_24660 1-106 2-107 0.96 0.98 0.91 0.93 0.93 0.93 30.1
P31224_2000496 MC24594 K9ZRT1_24594 1-166 81-245 0.99 0.67 0.97 0.66 0.66 0.93 50.0
Q9Z1R3_2000805 MC24524 A0A7J7RK29_24524 23-158 3-136 0.82 0.98 0.79 0.96 0.96 0.84 85.2
P11387_2000718 MC2452 A0A6J1W298_2452 1-53 19-71 1.0 0.75 1.0 0.74 0.74 1.0 83.0
Q8LC68_2000562 MC2450 A0A834Z4W7_2450 2-199 13-212 1.0 0.93 0.91 0.84 0.84 0.9 77.1
Q96A49_2000657 MC24421 A0A8B6DC02_24421 1-86 32-117 0.99 0.39 0.98 0.39 0.39 0.98 69.7
P20116_2000462 MC24338 A0A2P8WEW2_24338 1-63 18-83 0.94 0.8 0.68 0.56 0.56 0.73 31.8
P08833_2000632 MC24315 A0A061IPQ9_24315 1-82 1-82 0.99 1.0 0.98 0.99 0.99 0.97 78.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.