DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q96HE7_2001236 MC24288 A0A0R0LSK3_24288 20-426 4-253 0.94 0.99 0.45 0.75 0.75 0.53 15.6
Q9D394_2001012 MC24181 D6RET4_24181 1-167 1-167 1.0 0.89 0.99 0.88 0.88 0.96 79.0
Q02440_2000039 MC24156 Q02440_24156 2-582 35-615 1.0 0.91 1.0 0.91 0.91 1.0 100.0
P9WKD7_2000292 MC24083 A0A1Q9T970_24083 5-149 2-146 0.92 0.99 0.92 0.99 0.99 0.94 64.8
P45530_2000683 MC24046 A0A379FL97_24046 1-93 1-93 0.98 0.99 0.96 0.97 0.97 0.92 39.7
P69506_2000948 MC23961 A0A447J422_23961 1-60 2-61 0.98 0.36 0.97 0.36 0.36 0.96 55.0
Q9NRX4_2001140 MC23945 A0A3A4WHC5_23945 6-118 6-112 0.9 0.94 0.73 0.8 0.8 0.72 19.8
P04179_2000036 MC23876 A0A835P4B8_23876 1-83 8-90 1.0 0.4 1.0 0.4 0.4 1.0 90.3
Q8DIR2_2000576 MC23876 A0A6N2LYF9_23876 1-110 100-211 1.0 0.53 0.99 0.52 0.52 0.97 43.7
Q91062_2000225 MC23865 W5MPP9_23865 1-160 1-160 0.92 1.0 0.85 0.92 0.92 0.82 28.3
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.