DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9HJ63_2000150 MC26143 A0A7C1JEE3_26143 10-156 3-148 0.88 0.95 0.82 0.9 0.9 0.81 35.1
Q02039_2000311 MC26109 A0A7V9H5Q5_26109 1-59 44-92 0.98 0.4 0.4 0.22 0.22 0.52 13.3
Q7YXK2_2000647 MC26061 A0A0C2HGY4_26061 29-170 1-138 0.84 1.0 0.79 0.97 0.97 0.82 63.6
Q9Y657_2000090 MC26047 A0A556U3B6_26047 1-50 32-81 1.0 0.6 1.0 0.59 0.59 1.0 100.0
O29759_2000509 MC26031 T1A9X7_26031 2-75 6-79 0.97 0.79 0.94 0.77 0.77 0.91 50.0
P38937_2001555 MC25838 B6JUT1_25838 2-197 19-214 0.99 0.84 0.97 0.83 0.83 0.98 67.3
Q9K9K7_2000861 MC25818 A0A4Z2F972_25818 1-76 17-96 0.89 0.34 0.53 0.25 0.25 0.58 7.5
A0A0F4FZC1_2001204 MC2578 A0A6I3KM41_2578 18-224 6-225 0.92 0.88 0.46 0.42 0.42 0.62 36.4
P79085_2000425 MC25746 R0ISR1_25746 1-126 8-133 0.97 0.95 0.93 0.91 0.91 0.9 47.2
K7IM66_2000077 MC25725 A0A7R9H838_25725 1-175 143-317 1.0 0.47 1.0 0.47 0.47 0.99 86.8
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.