DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q8ZKF6_2001163 MC26457 A0A812YVH2_26457 78-512 2-455 0.85 1.0 0.81 0.91 0.91 0.77 35.7
P0A8I3_2001385 MC26388 A0A7X5X7F3_26388 1-217 5-142 0.85 0.96 0.35 0.56 0.56 0.37 10.0
Q83DI6_2000572 MC2635 A0A087SJB8_2635 2-91 38-137 0.98 0.71 0.92 0.61 0.61 0.84 19.0
P0A855_2000335 MC2635 A0A6D0M0R2_2635 6-127 1-122 0.91 0.99 0.91 0.99 0.99 0.95 95.0
Q9SXZ2_2000779 MC26280 A0A3M7KZI1_26280 8-160 1-153 0.94 1.0 0.89 0.95 0.95 0.83 34.4
P69797_2000192 MC26245 Z4WY56_26245 8-156 1-151 0.9 1.0 0.85 0.92 0.92 0.78 26.3
A1R6X9_2000451 MC26244 L8TLE5_26244 1-261 7-267 1.0 0.98 1.0 0.98 0.98 0.99 85.8
Q13506_2001606 MC26208 A0A5N5PCF4_26208 2-128 4-130 0.98 0.68 0.97 0.67 0.67 0.97 81.8
P07850_2000876 MC26164 A0A5A8C7B6_26164 2-248 1-286 1.0 0.98 0.96 0.82 0.82 0.92 46.1
Q9RN68_2000013 MC26147 Q9RN68_26147 1-123 7-129 1.0 0.93 1.0 0.93 0.93 1.0 100.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.