DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P23188_2000207 MC25706 A0A139WPK4_25706 1-334 16-349 1.0 0.96 0.99 0.95 0.95 0.97 70.6
P75455_2000183 MC2567 A0A7D7UGF6_2567 40-278 2-242 0.84 0.99 0.66 0.77 0.77 0.73 23.5
A0A0H2UNW2_2000727 MC25535 A0A2M7KHX3_25535 3-78 1-76 0.81 0.97 0.75 0.89 0.89 0.79 40.7
Q96DU7_2000514 MC25497 A0A3B3QWI8_25497 1-258 13-270 1.0 0.84 0.99 0.83 0.83 0.95 50.0
P33354_2000717 MC25456 A0A0R2DN65_25456 2-130 8-136 0.99 0.95 0.92 0.88 0.88 0.88 30.2
Q9H7P6_2001273 MC25361 A0A060YRB9_25361 1-146 16-161 1.0 0.74 1.0 0.74 0.74 1.0 93.8
Q9I1R6_2001002 MC25323 A0A7G5EJZ0_25323 5-159 106-257 0.98 0.59 0.82 0.52 0.52 0.8 41.5
Q08278_2000986 MC25322 Q5AEN6_25322 1-57 146-202 1.0 0.2 0.99 0.2 0.2 1.0 59.6
Q9Y4U1_2001192 MC25277 A0A6I9YCD7_25277 5-169 2-166 0.96 0.99 0.95 0.98 0.98 0.94 60.0
Q8UIR1_2000264 MC25220 A0A6J6Q9E6_25220 1-57 4-60 0.92 0.92 0.84 0.84 0.84 0.89 22.4
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.