DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q2W014_2001293 MC2927 A0A7C4QUE6_2927 1-78 8-84 1.0 0.92 0.96 0.9 0.9 0.96 51.2
A2I2W2_2001294 MC29264 A0A2E4VCU9_29264 1-179 26-172 0.98 0.82 0.72 0.73 0.73 0.72 31.1
P23295_2000672 MC29236 A0A4U0XS13_29236 25-392 1-367 0.92 1.0 0.91 0.99 0.99 0.92 62.7
B4EMD1_2001399 MC29165 A0A6G8NT09_29165 18-131 1-113 0.84 0.98 0.8 0.94 0.94 0.84 49.1
Q05506_2001094 MC29139 A0A179GU22_29139 1-124 164-286 1.0 0.39 0.98 0.39 0.39 0.96 58.8
P18317_2000233 MC29130 A0A6D0EIW3_29130 1-70 1-70 1.0 0.69 0.98 0.68 0.68 0.97 68.5
P0A9J8_2001022 MC29127 A0A3S4M4E2_29127 1-91 5-95 1.0 0.85 0.99 0.84 0.84 1.0 96.7
Q9LBK2_2000130 MC28982 A0A3M5J2Y7_28982 8-145 1-138 0.89 1.0 0.89 1.0 1.0 0.95 69.5
Q9UBU8_2001519 MC28877 A0A6P8J1D6_28877 2-158 6-318 0.93 0.98 0.9 0.48 0.48 0.88 20.3
P44492_2001246 MC28822 A0A7T0JRM1_28822 4-140 1-132 0.87 1.0 0.78 0.93 0.93 0.8 45.9
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.