DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O43405_2000655 MC28800 S7NK92_28800 1-100 7-106 1.0 0.91 1.0 0.91 0.91 0.99 93.0
Q82PP4_2001267 MC28783 A0A7K2NVC8_28783 1-97 9-113 1.0 0.93 0.95 0.82 0.82 0.91 34.2
Q9UQR0_2001615 MC2878 L8YDD0_2878 2-115 34-146 0.99 0.74 0.96 0.73 0.73 0.93 58.7
Q9CR21_2001104 MC28723 A0A2T7PYN4_28723 2-75 15-88 0.99 0.81 0.98 0.81 0.81 0.99 77.0
Q5KVS1_2001218 MC287 A0A2M9E830_287 2-81 12-102 0.99 0.89 0.83 0.68 0.68 0.72 20.8
O32003_2000689 MC28683 A0A395NZH7_28683 33-258 2-226 0.84 0.99 0.82 0.98 0.98 0.83 40.7
Q9X4B8_2000237 MC28675 A0A7R9P2Z4_28675 3-144 1-142 0.97 0.99 0.95 0.98 0.98 0.94 55.6
Q9Y4K3_2000826 MC28587 A0A1S3QHJ3_28587 1-57 15-71 1.0 0.74 1.0 0.74 0.74 1.0 82.4
Q9HYX7_2001502 MC2858 A0A4U0PZR7_2858 4-298 2-294 0.96 1.0 0.92 0.96 0.96 0.86 37.7
Q8W464_2000816 MC28513 A0A4D8YFW9_28513 1-36 36-71 1.0 0.41 0.99 0.41 0.41 1.0 83.3
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.