DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
P05119_2000406 MC2982 A0A1S3YTB5_2982 2-36 35-65 0.83 0.47 0.51 0.34 0.34 0.58 34.2
Q9S7P5_2000328 MC29792 A0A5J4ZRX1_29792 1-58 35-92 1.0 0.43 0.99 0.43 0.43 0.99 63.7
Q9SU14_2000071 MC29626 A0A7G2E7C9_29626 1-137 5-141 0.82 0.96 0.81 0.96 0.96 0.93 67.8
Q3ZDQ8_2001478 MC29574 A0A0X3QCA1_29574 1-57 7-63 0.98 0.65 0.98 0.64 0.64 0.97 87.7
P34047_2000072 MC2953 A0A388K4B2_2953 1-97 105-201 1.0 0.46 1.0 0.46 0.46 1.0 88.6
Q93HL1_2001648 MC29493 A0A7X0HIU0_29493 1-78 27-104 0.98 0.75 0.95 0.73 0.73 0.94 65.3
P36551_2000865 MC29475 F6TJW1_29475 2-335 9-342 0.99 0.98 0.99 0.97 0.97 0.99 86.5
P54132_2001384 MC29473 B2WPY5_29473 4-33 41-69 0.86 0.19 0.55 0.15 0.15 0.58 23.3
P21691_2000216 MC29367 G0VL22_29367 4-128 2-125 0.98 0.93 0.78 0.75 0.75 0.76 16.2
Q8NC06_2000757 MC2932 A0A811XSF4_2932 1-89 15-103 1.0 0.82 0.99 0.82 0.82 1.0 98.8
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.