DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q6PFD9_2000140 MC31205 A0A2H1C6M1_31205 28-147 2-121 0.82 0.99 0.81 0.99 0.99 0.91 55.8
Q868M7_2001136 MC31104 A0A6S7IAA4_31104 3-146 3-146 0.97 0.99 0.95 0.97 0.97 0.92 49.3
Q6P4R8_2001483 MC3103 A0A2I0T751_3103 1-76 30-105 1.0 0.36 0.99 0.36 0.36 1.0 81.5
P40399_2000595 MC31018 A0A4Z2IP49_31018 1-77 37-123 0.92 0.5 0.67 0.36 0.36 0.7 6.6
Q7Z589_2001052 MC30935 A0A0R3W1N6_30935 1-90 21-110 1.0 0.51 0.99 0.5 0.5 0.98 55.5
A3QJE4_2000368 MC30847 A0A7G2IVV2_30847 1-85 1-83 0.94 0.99 0.85 0.91 0.91 0.83 34.1
Q96CA5_2000929 MC30802 A0A5F7ZBM5_30802 1-90 7-96 1.0 0.83 1.0 0.82 0.82 0.99 96.6
A0A4Y1WDA8_2001603 MC30743 A0A4Y6UWL2_30743 4-171 2-175 0.87 0.99 0.78 0.86 0.86 0.74 23.4
Q9VXN9_2000377 MC30701 A0A816XCB6_30701 4-165 1-161 0.95 1.0 0.93 0.99 0.99 0.92 42.5
P50734_2001184 MC30684 A4IQB7_30684 2-84 28-110 0.93 0.75 0.89 0.72 0.72 0.86 44.5
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.