DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
O28415_2001406 MC3066 O28415_3066 3-92 1-90 0.86 1.0 0.87 1.0 1.0 0.92 100.0
P0AB26_2001130 MC30644 A0A7L5L508_30644 1-164 1-164 0.99 1.0 0.99 1.0 1.0 0.99 99.3
P27487_2000076 MC30635 A0A7J8FSA0_30635 1-248 4-251 0.96 0.98 0.96 0.98 0.98 0.98 90.7
Q9SBR3_2000988 MC30587 A0A6J5UD46_30587 3-288 1-286 0.97 1.0 0.96 0.98 0.98 0.93 69.3
Q9KVU3_2000761 MC30438 A0A7R8VTP6_30438 4-136 1-133 0.81 1.0 0.8 0.99 0.99 0.89 72.9
P35558_2001024 MC30435 A0A6R3G414_30435 1-288 46-333 1.0 0.73 1.0 0.73 0.73 1.0 90.6
Q8U4C0_2000481 MC30383 R9LZM5_30383 11-163 14-133 0.92 0.86 0.45 0.53 0.53 0.44 9.6
P61320_2001203 MC30379 F4SWM8_30379 1-177 27-203 1.0 0.87 1.0 0.87 0.87 0.99 100.0
Q9I2B5_2000369 MC30379 A0A1Q6DQ72_30379 3-183 35-244 0.97 0.83 0.58 0.46 0.46 0.46 9.3
P75884_2000366 MC30379 A0A3N5TPC2_30379 12-194 7-187 0.93 0.95 0.51 0.52 0.52 0.43 11.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.