DPCstruct Metaclusters

⬡ Domain Classification in Structural Space
Properties CATH SCOP

The DPCstruct pipeline applied the Density Peak Clustering (DPC) algorithm to roughly 15 million representative AlphaFold2- predicted structures from the Foldseek Cluster database (a representative set of the AlphaFold Database, AlphaFoldDB v4.0), producing 28,246 structural metaclusters without any manual annotation. Because protein structure is more conserved than sequence over evolutionary time, DPCstruct recovers remote homologs, including proteins sharing a common fold at less than 30% sequence identity, that purely sequence-based methods typically miss.

Use the toggle buttons to switch between the Properties view (intrinsic structural metrics and Pfam annotations), the CATH fold annotations, or the SCOP fold annotations. Click any MCID to open its detail page, where you can explore the sequences and launch the integrated PDBe-Mol* 3D viewer.

SCOP Fold MCID DPC Target Q.Range T.Range Q.Cov T.Cov Q.TM-Score T.TM-Score A.TM-Score lDDT pIdent
Q9X1X7_2000352 MC37770 A0A1W9P0S1_37770 39-294 2-257 0.86 0.99 0.83 0.96 0.96 0.8 41.8
Q92547_2000009 MC37675 Q92547_37675 1-97 189-285 1.0 0.28 1.0 0.28 0.28 1.0 100.0
Q60611_2000087 MC37662 A0A3Q3A207_37662 1-59 56-114 0.98 0.48 0.97 0.48 0.48 0.98 84.7
Q9VKM6_2001359 MC37632 A0A2T7PSV0_37632 2-68 3-69 0.98 0.76 0.9 0.71 0.71 0.95 52.2
P10486_2001473 MC37608 A0A5N9VUF1_37608 1-165 107-271 0.99 0.46 0.97 0.46 0.46 0.97 89.0
H6W1B5_2001550 MC3756 A0A2P4XD04_3756 1-213 5-217 0.99 0.98 0.98 0.98 0.98 0.96 59.6
Q04609_2000408 MC37559 F6Z113_37559 2-239 1-238 0.98 1.0 0.98 1.0 1.0 0.99 93.6
P41772_2000869 MC37552 A0A4V5NAN4_37552 1-39 1-40 0.93 0.6 0.89 0.57 0.57 0.94 45.0
P30176_2000281 MC37540 S1IFR0_37540 17-155 2-140 0.87 0.99 0.87 0.99 0.99 0.94 97.8
Q4K376_2000060 MC37520 Q8CWU2_37520 1-104 101-204 1.0 0.38 1.0 0.38 0.38 1.0 100.0
Legend
  • Agreement between SCOP Folds and DPCstruct Metacluster Domains:
  • SCOP Fold: SCOP fold identifier.
  • MCID: DPCstruct metacluster identifier.
  • DPC Target: Target DPCstruct protein domain.
  • Q./T.Range: Amino acid coordinate ranges for query and target.
  • Q./T.Cov: Coverage metrics indicating how much of each domain was covered in the alignment.
  • A.TM-Score: Template Modeling score of the structural alignment (0-1).
  • lDDT: Local Distance Difference Test score.
  • pIdent: Percent sequence identity between query and target.